Sultosilic Acid Piperazine Salt

N-Ethyl-a-aminomethylpyrrolidine Phosphorus trichloride 2-Methoxy-5-ethylsulfonylben2oic acid [Pg.1433]

A solution of 17.22 g of N-ethyl-0(-aminomethylpyrrolidine in 360 ml of pyridine is placed in a 1 8 balloon flask. A solution of 3.51 g of phosphorus trichloride in 40 ml of pyridine is added at ambient temperature. After the mixture has been stirred for 1 hour, 10 g of 2-meth-oxy-5-ethylsulfonylben20ic acid is introduced. The mixture is heated under reflux for 4Vi hours. After cooling, the solvent is evaporated under vacuum and the residue is dissolved in 200 ml of 20% sodium hydroxide. The solution is extracted with 200 ml of chloroform. [Pg.1433]

The organic solution is dried and filtered and the solvent is evaporated under vacuum the residue is dissolved in 150 ml of ethanol and the solution is acidified with hydrochloric acid. The hydrochloride is dried without heating and recrystallized from 100 ml of absolute ethanol. 7.2 g of N-(1 ethyl-2-pyrrolidyl-methyl-2-methoxy-5-ethylsulfonylbenzamide hydrochloride is produced. Melting point 190°C to 193°C. [Pg.1433]

Societe D Etudes Scientifiques et Industrielles de L lle-de-France British Patent 1,394,559 May 21,1975 [Pg.1433]

Chemical Name 2-Hydroxy-5-[ [(4-methylphenyl)sulfonyll oxyl benzenesulfonic acid, piperazine salt [Pg.1433]

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