Sultam templates

Scheme 6 Sultam templates in enantioselective H-atom transfer...

In a series of papers24a c, Oppolzer et al. introduced another procedure for the enantioselec-tive amination of enolates based on the A-acyl camphor sultam 1 as a chiral template and 1-chloro-l-nitroso cyclohexane (2) as electrophile. 

Lewis acidity L Other notable additions to the chiral pool include chiral bicyclic lactams and further chiral sultam derivs., while syntheses with chiral acyl carbanion equivalents, silanes N-acyl-immonium salts and pyran templates are of obvious application, the last-mentioned being adaptable for a reiterative generation of the key polypropionate chain of macrolide antibiotics. Asym. syntheses via organometallics have also been succinctly reviewed" ... 

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