Sulpiride Antacids

PHENOTHIAZINES, SULPIRIDE ANTACIDS 1 levels of these antipsychotics 1 absorption Separate doses by 2 hours (in the case of sulpiride, give sulpiride 2 hours after but not before the antacid)... 

Antacids containing aluminium/magnesium hydroxide or magnesium trisilicate can reduce the serum levels of chlorpromazine which would be expected to reduce the therapeutic response. Sucralfate and an aluminium/magnesium hydroxide antacid can reduce the absorption of sulpiride. In vitro studies suggest that this interaction may possibly also occur with other antacids and phe-nothiazines. There seem to be no clinical studies or reports confirming the anecdotal evidence of a possible reduction in the effects of haloperidol by antacids. 

A study in 6 healthy subjects found that the bioavailability of a single 100-mg dose of sulpiride was reduced by 40% by sucralfate 1 g and by 32% by 30 mL of Simeco (aluminium/magnesium hydroxide and simeticone). When either the sucralfate or the antacid were taken 2 hours before sulpiride the reduction in bioavailability was only about 25%, and no change in hioavailahility was seen in one subject when the sucralfate was given 2 hours after the sulpiride. ... 

Gouda MW, Hikal A Babhair S ElHofy SA, Mahrous GM Effect of sucralfate and antacids onthebioavaUability of sulpiride mhamans.Int J Pharmaceutics ( 9Z4) 22,257-63. 

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