Sulfur trioxide sulphonation

The most strained benzocycloalkene studied, cyclobutabenzene, undergoes extensive ipso attack upon sulphonation. In 95% sulfuric acid, cyclobutabenzene forms polyxylylene and ring cleavage products exclusively. The extent of ipso attack can be decreased in sulfur trioxide media where moderate -selectivity is observed. ... 

Distilled fatty methyl esters with low iodine values are used as the starting raw material for the production of SME. The fatty methyl ester is first reacted with sulfur trioxide at 80-90°C in a falling-film reactor. The dark product obtained from this process is bleached using hydrogen peroxide. After bleaching, the lighter color product is neutralized with alkali to produce an a-sulphonated methyl ester. 

Sulfur trioxide trimethylamine complex. See Trimethylamine sulfur trioxide Sulisobenzone. See Benzophenone-4 Sulphadione. See 4,4 -Diaminodiphenyl sulfone Sulphamic acid. See Sulfamic acid Sulphanilamide. See Sulfanilamide Sulphanilic acid. See Sulfanilic acid Sulphonated Lorol Liquid MA, MR. See MEA-lauryl sulfate... 

The first anionomer has a sulphate end fimctionality similar to that of heparin. Heparin has been shown to be responsible for the binding of a magnitude of proteins in-vivo (5). To prepare the anionic moiety having sulphonic acid at both chain ends, the PTMC diol was employed as a nucleophile to the electrophilic sulfur trioxide trimethylamine complex, giving the PTMC disulphonate as a product. 

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See also in sourсe #XX -- [ , ]

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