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Sulfonic acids Knoevenagel reaction

J,V-Unsaturated carboxylic acids and their derivatives are valuable synthetic intermediates for various natural products. Two typical multi-step processes for the synthesis of p.y-unsaturated acids, Knoevenagel reaction/isomerization with base and allylic cyanide/hydrolysis,3 are those most commonly used. Other new methods have been developed 4-7 however, there is a problem with E/Z stereoselectivity. One straightforward way to obtain p,y-unsaturated acids is by the carboxylation of an allyl metal Intermediate. In the substituted allylic series, the reaction usually occurs at the more sterically hindered terminus. A stereospecific route for the synthesis of homogeranlo acid and homoneric acid by carboxylation of the lithiated allylic sulfone... [Pg.92]

Further projects dealt with the fabrication of heterogeneous, basic or acidic solid-state catalysts or adsorbents carrying, for instance, amino or sulfonic acid groups. Amino-functionalized silicas were prepared and analyzed for the catalytic activity in Knoevenagel condensation reactions of aldehydes or ketones with ethyl cyanoace-tate ions by Macquarrie et al.154 155 Recently, Zhang et al.156,157 reported on the successful preparation of amino-functionalized silica thin films by means of the EISA approach. [Pg.67]


See other pages where Sulfonic acids Knoevenagel reaction is mentioned: [Pg.182]    [Pg.589]    [Pg.79]    [Pg.138]    [Pg.362]    [Pg.362]    [Pg.824]    [Pg.858]    [Pg.362]    [Pg.356]    [Pg.610]   


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