Sulfonamides structure-activity correlation

Table 16.8. Structure-Activity Correlation in the Sulfonamide Series" (Seydel, 1966)...

Miller, G.H., Doukas, P.H. and Seydel, J.K. 1972. Sulfonamide structure-activity relationship in a cell-free system. Correlation of inhibition of folate synthesis with antibacterial activity and physico-chemical parameters. J. Med. Chem. 15 700-706. 

TJreviously, we correlated bacteriostatic activity and structure of various series of N-l substituted sulfonamide drugs with the free energy related substituent constants of the N-l substituent (I). For a series of N-l heterocyclic derivatives, activity data obtained by Kriiger-Thiemer and Biinger (<3) were well correlated by Equation 1. In Equation 1, C... 

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