Sulfasalazine juvenile rheumatoid

Sulfasalazine also is indicated for use in rheumatoid arthritis and juvenile rheumatoid arthritis. Refer to the monograph in the Biologic and Immunologic Agents chapter. 

Immunologic There have been further reports of drug rash with eosinophilia and systemic symptoms (DRESS) in patients taking sulfasalazine, a 47-year-old white Brazilian woman who developed DRESS after 8 weeks [104" ], a 60-year-old man with polyarthritis who also developed fulminant liver failure after additional vancomycin treatment [lOS ], and a 68-year-old woman in whom the reaction may have been precipitated by the addition of sulbactam -f ampicillin [lob ll. In another case, drug-induced hypersensitivity syndrome was associated with reactivation of an infection with human herpesvirus-6 in a 15-year-old boy with juvenile rheumatoid arthritis who was taking sulfasalazine [107 ]. 

Sulfasalazine is effective in rheumatoid arthritis and reduces radiologic disease progression. It has been used in juvenile chronic arthritis and in ankylosing spondylitis and its associated uveitis. The usual regimen is 2-3 g/d. 

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