Sulfapyridine analysis

Berge and Deye studied the effect of column surface area on the retention of polar solutes [18]. They found that there was a linear relationship between retention and the surface area. 4-Hydroxy benzoic acid was used as a model acidic compound, and sulfamethazine, sulfanilamide, sulfi-somidine, and sulfapyridine were used as the model basic compounds. The separations were carried out on a packed Nucleosil Diol column with a methanol-modified carbon dioxide as the mobile phase. The UV detector was used for the analysis. It was observed that 0.1% acetic acid for the acidic solutes and 0.1% isopropylamine for basic solutes was required in the methanol to achieve the separations. The efficiency was found to be similar for 100-, 300-, and 500-A packing materials. 

It is imperative that the diagnosis of primary (idiopathic) pulmonary fibrosis not be made until all known and potentially treatable causes of the fibrotic disease have been excluded. This can be accomplished by a systematic, thorough analysis of the patient s occupational history, family history, history of recurrent pneumonias, and history of drug use, including the use of immunosuppressive agents, antimicrobials, and miscellaneous drugs such as hydrochlorthiazide, gold salts, chlorpropamide, sulfapyridine, hydralazine, and amiodarone. 

McGrane, M. O Keeffe, M. Smyth, M.R. The analysis of sulphonamide drug residues in pork muscle using automated dialysis, Anal.Lett., 1999, 32, 481-495. [LOD 40 ng/g sulfadiazine sulfathiazole sulfapyridine sulfamerazine suRamethizole sulfamethazine sulfamethoxypyridazine sulfachlorpyridazine sulfisoxazole]... 

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