Sulfabenzamide / sulfacetamide sulfathiazole

Contraindications Renal dysfunction, hypersensitivity to sulfabenzamide, sulfacetamide, sulfathiazole or any component of preparation... 

HPLC on pBondapak Ph column with UV detection at 280 nm has been used for the determination of sulfacetamide, sulfabenzamide and sulfathiazole in a triple sulfa cream. The mobile phase consists of a 7 3 mixture of 0.01 M ammonium hydrogen phosphate and methanol (pH 7.2). The proposed method has been shown to give better results for sulfacetamide assay compared with those of the USP method (97). Sulfacetamide, sulfadiazine, sulfamerazine and sulfamethazine in mixtures and in pharmaceuticals have been determined by HPLC using a nonpolar column with methanol-0.02 M potassium dihydrogen phosphate in water as the mobile phase and a variable wavelength UV detector. The method is precise with relative standard deviations of 2.1, 0.6,1.9 and 1.6% respectively for the four compounds. The preservatives do not interfere with the method (98). 

Simultaneous diaveridine, phthalyl sulfathiazole, pyrimethamine, succinyl sulfathiazole, sulfabenzamide, sulfacetamide, sulfachloropyrideizine, sulfadiazine, sulfadimethoxine, sulfaguanidine, sulfamerazine, sulfameter, sulfamethazine, sulfamethizole, sulfamethox-yp3Tidazine, sulfamoxole, sulfanilamide, sulfaniUc acid, sulfapjnidine, sulfaquinoxaline, sulfathiazole, sulfisomidine, sulfisoxazole, trimethoprim... 

The cream contains sulfathiazole (benzenesulfonamide,4-amino-N-2-thiazolyl-N 1 -2-thiazolylsulfanilamide) 3.42%, sulfacetamide (acetamide,N-[(4-aminophenyl)sulfonyl]-N-sulfanilylacetamide) 2.86%, and sulfabenzamide (benza-mide,N-[(4-aminophenyl)sulfonyl]-N-sulfanilylbenzamide)... 

Sulfonamides having a free j )-amino group are readily assayed by titration with nitrous acid. The sulfonamide function may also be titrated with base, such as lithium methoxide. The majority of the sulfas listed in the U.S. Pharmacopeia XXII, however, are assayed by chromatographic methods, particularly high performance liquid chromatography (49). Sulfonamides for which assays are listed in the U.S. Pharmacopeia XXII-National Formulary XVII include the following sulfacetamide, sulfabenzamide, sulfadiazine, sulfadoxine, sulfamerazine, sulfamethazine, sulfamethizole, sulfamethoxazole, sulfapyridine, sulfasalazine, sulfathiazole, sulfinpyrazone, sulfis ox azole, sulfisoxazole acetyl, sulfisoxazole diolamine, sulfoxone, triple sulfa, dapsone, and various combinations with prednisolone, pyrimethamine, and trimethoprim. 

Sulfonamides sulfacetamide, sulfadiazine, sulfa-merazine, sulfathiazole, sulfmnethazine, sul meth-oxypyridazine, sulfachloropyridazine, sulfamono-meftoxine, sulfabenzamide, sulfadimeflioxine, sulfa-... 

Figure 11.9 Separation of sulfonamides in human urine (top) and cow milk (bottom). Mobile phase was 0.07 M SDS-6% 1-propanol in 0.02 M phosphate buffer at pH 3.0, Compounds (1) sulfacetamide, (2) sulfadiazine, (3) sulfamerazine, (4) sulfathiazole, (5) sulfamethazine, (6) sulfamethoxypyridazine, (7) sulfachloropyridazine, (8) sulfamonomethoxine, (9) sulfabenzamide, (10) sulfadimethoxine, (11) sulfaquinoxaline and (12) sulfisomidine. Reprinted from Ref 30 with permission of Elsevier.

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