Sugar moieties, inductive effects

Activation of the coenzyme for hydride transfer involves a complex interplay among a number of factors. These include distortion of the nicotinamide/dihy-dronicotinamide ring, solvation, direct electrostatic interactions, conformation of the side chain at C-3, conformation around the glycosyl bond, and inductive effects directed at the sugar moiety. The following sections will provide a discussion of these interactions and their potential mechanistic impact. 

A growing number of coenzyme analogs have been prepared containing modifications in the nicotinamide sugar moiety. These modifications focus on three primary interactions inductive effects, tolerance of sugar substituents (anomeric configuration), and nucleoside flexibility (the importance of an intact furanose... 

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