Succinimidyl carbonate formation

Fluorenylmethyl JV-succinimidyl carbonate (Fmoc-ONSu) 731 is particularly recommended for the preparation of Pmoc derivatives of amino acids, since it avoids the problems arising from the formation of mixed anhydrides [155]. 

EPR experiments on carbon-centred radicals with either a- or /J-boronic ester substituents have been reported.168 While the a-substituted radicals were modestly thermodynamically stable, the /J-substituted radicals underwent easy /J-climination. An EPR experiment on the photo-oxidation of phenolic compounds containing at least one free ortho position has indicated the formation of persistent secondary radicals derived from dimerization or polymerization from C-0 coupling.169 The structure of the succinimidyl radical has been re-examined using density functional theory with a variety of basis sets. The electronic ground state was found to be of cr-symmetry allowing for facile -scission. These conclusions were also predicted using MP2 but... 

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