Succinic acids succinimidyl, 3-

Succinimidyl succinate 1 is typically prepared by the reaction of succinic anhydride with mPEG under different reaction conditions to give the corresponding succinic acid-terminated polymer, followed by diimide-mediated esterification with N-hydroxysuccinimide [61]. The DMAP accelerated ring-opening reaction as well as melt synthetic method have also been published [62]. 

The new method provides an easy preparation of N-protected amino acid active ester derivatives using cheap reagents, in a reaction where the by product is water soluble and easily eliminated from the reaction mixture. The process is illustrated by the isolation of the N-succin-imidyl ester of BOC-Alanine in 94 % yield from activation of BOC-Ala with 1,2,2-2-tetrachloro-ethyl N-succinimidyl... 

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