12 - substrates physiologically-based pharmacokinetics

While rate equations can be solved and metabolic rates can be estimated and determined easily in vitro because of the control of variables (specifically, substrate concentration), the situation is much more difficult in vivo. Here the advent of physiologically based pharmacokinetic (PBPK) models has offered a powerful tool for examining metabolic interactions that occur following exposure to chemical mixtures (see Chapter 3). 

Fenneteau F, Poulin P, Nekka F. 2009. Physiologically based predictions of the impact of inhibition of intestinal and hepatic metabolism on human pharmacokinetics of CYP3A substrates. 

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