Substrates Containing a Chalcogenide Group

Since the mechanism of chalcogenide-MBH reaction involved the Michael addition of chalcogenide to electron-deficient olefins and the intramolecular Michael addition reaction of a sulfide group to an enone moiety in an acidic medium is known, Kataoka et al. envisaged that the tandem Michael aldol 

CH2=CH-CH2, Bn, Me, CH3CECCH2, PhCH=CHCH2, CH3CH(0H)CH2 (epoxide as electrophile) 

As stated in Chapter 1.7, the low reaction rates usually associated with the MBH reaction can be increased by pressure, the use of ultrasound, and by 

R = Ph, 4-EtPh, 4-BiPh, 4-CIPh, 2-N02Ph, 3-N02Ph, 4-N02Ph, 2-pytidyl, 3-pyridyl, cinnatnyl, n-Pr 

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