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Substrate selectivity of the phosphorylation-dephosphorylation switch

We now study how, as a kinetic circuit, a phosphorylation-dephosphorylation switch can amplify the affinity difference between two competing substrate [Pg.113]

Without the loss of generality, we assume 1. This means the affinity of the kinase for the protein 1 is greater than that of the protein 2. [Pg.114]

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Dephosphorylate

Dephosphorylation

Dephosphorylation selective

Of 2 -phosphorylated

Selection of substrate

Selective phosphorylation

Selectivity phosphorylation

Selectivity switch

Substrates selection

The Substrate