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Substitution rate matrix

A simplified substitution rate matrix used in ML and distance phylogenetic analysis is presented in Figure 14.6. The matrix is analogous to that presented in Figure... [Pg.335]

Figure 14.6. Simplified substitution rate matrix used in ML and distance phylogenetic analysis. The off-diagonal values a represent a product of an instantaneous rate of change, a relative rate between the different substitutions, and the frequency of the target base. In practice, the forward rates (upper triangular values) are presumed to equal the reverse rates (corresponding lower triangular values). The diagonal elements are nonzero, which effectively accounts for the possibility that more divergent sequences are more likely to share the same base by chance. In the simplest model of sequence evolution (the Jukes-Cantor model), all values of a are the same all substitution types and base frequencies are presumed equal. Figure 14.6. Simplified substitution rate matrix used in ML and distance phylogenetic analysis. The off-diagonal values a represent a product of an instantaneous rate of change, a relative rate between the different substitutions, and the frequency of the target base. In practice, the forward rates (upper triangular values) are presumed to equal the reverse rates (corresponding lower triangular values). The diagonal elements are nonzero, which effectively accounts for the possibility that more divergent sequences are more likely to share the same base by chance. In the simplest model of sequence evolution (the Jukes-Cantor model), all values of a are the same all substitution types and base frequencies are presumed equal.
PAM Point Accepted Mutation. The PAM matrix is a frequency table representing substitution rates for closely related proteins at the particular evolutionary distance represented by multiple sequence alignments. [Pg.181]

Figure 2 Maximum likelihood tree. Distance analysis was performed using PUZZLE 4.0.2 (Strimmer and von Haeseler, 1996). Because of the unequal rate of nucleotide substitution among the positions, the matrix of maximum likelihood distances was computed using the model of Tamura and Nei (1993) with gamma distance corrections for substitution rate heterogeneity. Figure 2 Maximum likelihood tree. Distance analysis was performed using PUZZLE 4.0.2 (Strimmer and von Haeseler, 1996). Because of the unequal rate of nucleotide substitution among the positions, the matrix of maximum likelihood distances was computed using the model of Tamura and Nei (1993) with gamma distance corrections for substitution rate heterogeneity.
Substituting Equation (10.46) in the set of copolymerization rate equations, the rate matrix can be rewritten as... [Pg.238]

Substitution of this for the golden-rule expression (1.14) together with the renormalized tunneling matrix element from (5.60) gives (5.64), after thermally averaging over the initial energies E-,. In the biased case the expression for the forward rate constant is... [Pg.87]

Similar substitution into Equations 16.10-16.12 gives masses of the basis entries at the end of a time step, Equations 16.13-16.14 yields the residual functions, and Equations 16.18-16.21 gives the entries in the Jacobian matrix. In evaluating the Jacobian, the derivatives dr /dnw and dr /dm, can be obtained by differentiating the appropriate rate law (Eqn. 17.9, 17.12, or 17.21), as discussed in Appendix 4, or their values determined just as efficiently by finite differences. [Pg.253]

Other papers in the series Chemometrical Analysis of Substituent Effects are on additivity of substituent effects in dissociation of 3,4-178 or 3,5-179disubstituted benzoic acids in organic solvents and on the ort/zo-effect180. In the last-mentioned, data for the dissociation of ortto-substituted benzoic acids in 23 solvents are combined with data on the reactions with DDM (Section IV.C) and with other rate and equilibrium data bearing on the behaviour of o/t/ o-substituents to form a matrix involving data for 69 processes and 29 substituents. [Pg.507]

Static experiments approach the situation described in Figure 2b. The appropriate boundary conditions are set and Laplace transformation performed by Bird et al. (16). Differentiation of their equations, evaluation at x = 0, and substitution in Fick s first law will provide the mass transfer rate at the interface. Diffu-sivities in the matrix and in water can also be derived. [Pg.177]

In order to regulate the convergence of the iterative process by damping or accelerating its rate according to convenience, the basic procedure has been further refined [88]. This is achieved by substituting the numerical reduced Hamiltonian matrix by a new one... [Pg.247]

Spike the matrix substitute with a realistic, expected amount of test compound and repeat the process of step 4. If there are significant losses evident in step 4 and these have not been eliminated, then a procedure modification is already indicated since a higher overall concentration factor will be required to reach the predetermined limit of sensitivity or lower limit of acceptable concentration of the test compound. At any rate, it will be necessary to establish that the realistic quantity of test compound is handled by the workup procedure in ess-... [Pg.411]


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