1-Substituted 1,2,4-triazole 4-oxides deoxygenation

Substituted 1,2,3-triazole 1-oxides 448 have been reported to undergo electrophilic and nucleophilic aromatic substitution and are subject to debromination, proton-metal exchange, and halogen-metal exchange followed by electrophilic addition. Transmetallation and cross-coupling have not been described. 3-Substituted 1,2,3-triazole 1-oxides 448 can be proton-ated or alkylated at the O-atom and they can be deoxygenated and deal-kylated. The individual reactions are described in Section 4.2.7.1-4.2.7.14. 

The 1-substituted 1,2,4-triazole 4-oxides with the basic structure 532 are hygroscopic. They form hydrates, which lose the water by heating to melting or by recrystallization from anhydrous solvents. 1,2,4-Triazole 4-oxides 534 are 4 p/< , units weaker as a base than their deoxygenated progenitor 533 (1972JPR101). 

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