Substituted Benzenes The Alvarez-Manzaneda Synthesis of -Taiwaniquinone

Mamoru Tobisu and Naoto Chatani of Osaka University have found (Chem. Lett. 2009, 55,710) for the conversion of aryl ethers such as 9 to the tertiary amine. Masahito Ochiai of the University of Tokushima observed (J. Am. Chem. Soc. 2009,131, 8392) the remarkable inversion of an arene sulfonamide such as 11 to the protected aniline 12. Matthias BeUer of the Universitat Rostock established Angew. Chem. Int. Ed. 2009, 49, 918) a Pd-mediated procedure for the conversion of even a congested aryl halide 13 to the phenol 14. 

Professor Knight has also Tetrahedron Lett. 2007,48, 7906) established a route to poly-substituted pyrroles 10, by iodination of alkynyl sulfonamides such as 9. Similarly, Richard C. Larock of Iowa State University foimd J. Org. Chem. 2007, 72, 9643) that 1-Cl cyclized methoximes such as 11 to the corresponding iodo isoxazole 12, and Stephen L. Buchwald of MIT uncovered Organic Lett. 2007, 9, 5521) the cycUzation of an enamide such as 13 

Professor Buchwald has also developed Angew. Chem. Int. Ed. 2007, 46, 7236) a protocol for the Pd-mediated a-arylation of aldehydes. This procedure converted an o-halo aniline 29 to the indole 31. In a C-H activation-based approach, Mark Lautens of the University of Toronto demonstrated Organic Lett. 2007, 9, 5255) that Pd-catalyzed condensation of 32 with the aniline 33 led to the indole 34. 

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Substituted Benzenes The Alvarez-Manzaneda Synthesis of (-)-Taiwaniquinone G... 

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