Substantia nigra apomorphine response

Fig. 14. Caudate nucleus (A), and nucleus accumbens (B), substantia nigra, pars compacta (C), and substantia nigra, pars reticulata (D). Log dose-response curves of glucose utilization folloiving the intravenous administration of apomorphine. Data are presented as means SEM. (From McCulloch et al, 198Id.)...

Fig. 15. Substantia nigra, pars compacta. Metabolic response to apomorphine (0.5 mg/kg) (expressed as percent change in cerebral glucose utilization from control animals) in four groups of animals which had been pretreated for 21 days with saline (SAL), haloperidol (HAL) (1 mg/kg/day), haloperidol with lithium in diet (Li /HAL), and lithium in diet (Li" ). Data are presented as mean SEM. The response to apomorphine in the animal chronically treated with haloperidol (HAL) differs significantly from that with all other treatments. Glucose utilization in control animals was 56 4 pmol/100 g/ min. (Data from McCulloch, Savaki, Pert, Bunney, and Sokoloff, unpublished.)...

Grome, J. J., and McCulloch, J., 1981a, The effects of chloral hydrate anaesthesia on the metabolic response in the substantia nigra to apomorphine. Brain Res. 214 223-228. 

---