Subsite-specific properties clusters

The problem of performing site-specific chemistry at one iron site in a [4Fe-4S] cluster requires interrelating the reactivity of three of the iron atoms such that the fourth site can react independently. This relationship has been achieved by the synthesis of a semirigid tridentate thiolate ligand that readily binds several types of cubane clusters. The details of the synthesis and reactivity of site-differentiated clusters will be provided in Section IV. We next turn to the topic of subsite-specific properties observed in biological systems. 

With subsite-differentiated clusters in hand, we turn to their applications in examining subsite-specific properties of native [4Fe-4S] clusters by the synthetic analogue approach. The potentially most important applications at this stage of development of subsite-specific cluster chemistry are listed below. 

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