Sublethal plasma effect

Apoptosis Versus Necrosis in Piasma Treatment of Cells Sublethal Plasma Treatment Effects... 

Ruby, S.M., D.R. Idler, and Y.P. So. 1986. The effect of sublethal cyanide exposure on plasma vitellogenin levels in rainbow trout (Salmo gairdneri) during early vitellogenesis. Arch. Environ. Contam. Toxicol. 15 603-607. 

The effect which originally defined the compound is the "shock which AT produces on i.v. injections into guinea pigs. Of activated, AT-containing rat plasma 3 ml/kg may be lethal. Purified hog AT is lethal at doses of 25 - 5o wg/kg (Bodammer, 1967). It is thus more toxic than histamine, even on a weight basis. The main adverse effect is bronchospasm which leads to asphyxia. When an animal has recovered from a sublethal dose a second injection of AT will have a much less severe or no bronchoconstrictor effect, i.e. the action on the bronchi is tachyphylactic. The constrictor action is preceded by a short period of respiratory stimulation which effect is not tachyphylactic (Bodammer and Vogt, 1967). 

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