Subject macrolide antibiotics

Barzaghi N, Gatti G, Crema F, Faja A, Monteleone M, Amione C, Leone L, Perucca E. Effect of flurithromycin, a new macrolide antibiotic, on carbamazepine disposition in normal subjects. Int J Chn Pharmacol Res 1988 8(2) 101-5. 

Many Hj antihistamines are metabolized by CYPs. Thus, inhibitors of CYP activity such as macrolide antibiotics (e.g., erythromycin) or imidazole antifungals (e.g.,ketoconazole) can increase Hj antihistamine levels, leading to toxicity. Some newer antihistamines, such as cetirizine, fexofenadine, levocabastine, and acrivastine, are not subject to these drug interactions. 

Ansamycin Antibiotics.—The ansa macrolide antibiotics, formerly composed of the rifamycins, streptovaricins, tolypomycins, and geldanamycin, but also now including the maytansines (see below), have aroused considerable interest as antiviral and antimicrobial agents, and as inhibitors of RNA tumour virus reverse transciptases. The chemistry etc. of this interesting class of antibiotics has been the subject of a recent review by Rinehart. Streptovaricins. Rinehart and collaborators have re-examined the structures... 

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