Subject from saturated heterocycles

This voiume covers the 1972 iiterature on the subject and is the second report created from the umbrella title Aliphatic, Alicyclic and Saturated Heterocyclic Chemistry mentioned above. To be published in mid-1974 (still available Vol. 1 20.00)... 

Isolation of the hydrocarbons from other lipids The total lipid extract may be subjected to removal of elemental sulphur by passage through an activated copper column (Blumer, 1957) and then to chromatographic separation on adsorbent columns or thin layer plates. For column chromatography, silic el is used with a short alumina bed on the top of the silic el. Both adsorbents should be partially deactivated by the addition of water (2—5%) to prevent the formation of artifacts (Blumer, 1970). Elution with a non-polar solvent such as hexane or pentane and subsequently with mixtures of non-polar and polar solvents, e.g. benzene and methanol, permits the isolation of several fractions containing saturated, unsaturated, aromatic hydrocarbons and more polar compounds (methyl esters, alcohols, acids, phenols and heterocyclic compounds). The interference from esters encountered in the isolation of aromatic hydrocarbons can be avoided prior to separation by saponification of the esters of fatty acids, which are easily removed. 

In Chapter 6 it was mentioned that certain saturated nitrogen heterocycles such as piperidine and piperazine are common components of many drugs. These groups are cyclic amines and are also subject to metabolism by MFO by the mechanism outlined above. The amine and carbonyl components that result from this process, however, remain attached to each other by the remainder of the ring. This makes it likely that they will react with each other since amines are nucleophiles and aldehydes and ketones are electrophiles. Thus there are two possible outcomes ... 

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