Studies of Other Superfamilies and Fold Classes

Some Examples of Enzyme Superfamilies Whose Members Mediate a Common Fundamental 

Stabilization of enolate anions generated from abstraction of a proton a to a carboxylate Hydrolysis, phosphoryl group transfer via hydrolytic nucleophilic substitution Stabilization of diverse oxyanion intermediates via metal-assisted catalysis Schiff base dependent formation of an electron sink  

Stabilization of oxyanion intermediates derived from thioesters 

Although a full exposition of these additional superfamilies is beyond the scope of this discussion, a short description of two, the vicinal oxygen chelate fold (VOC) superfamily and the haloacid dehalogenase (HAD) superfamily, are included. Neither of these superfamilies belongs to the a/(3 barrel fold class and a discussion of the way in which each delivers function provides an important contrast to our discussion of the enolase superfamily. 

The VOC Superfamily Reengineering the Scaffold through Wholesale Domain Shuffling 

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