Strychnine oral reference dose

The strychnine oral reference dose (RfD) of 0.0003 mg/kg/ day or 0.02 mg/day for a 70 kg person is derived from the Seidl and Zbinden (1982) short-term to subchronic study by applying an uncertainty factor of 10,000. This factor accounts for extrapolation from a less than chronic to a chronic exposure study, extrapolation from animals to humans, and differences in sensitivity among the human population. An additional factor of 10 is used because an LOAEL/FEL (2.5 mg/kg/day) was utilized in the estimation of the RfD instead of an NOAEL. The immediately dangerous to life and health (IDLH) dose for strychnine by NIOSH REE is 0.15 mg/m and the current OSHA PEL is 0.15mg/m. ... 

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See also in sourсe #XX -- [ ]

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