Structures of ABC Transporters

Teodori E, Dei S, Martelli C, Scapecchi S, Gualtieri F (2006) The functions and structure of ABC transporters Implications for the design of new inhibitors of P-gp and MRP1 to control multidrug resistance (MDR). Curr Drug Targets 7 893-909. 

The function and structure of ABC transporters along with their role and also in acquired immunodeficiency syndrome (AIDS) related lymphoma has been reviewed recently [68-72],... 

Figure 6 Molecular structure of ABC transporters, such as P-gp and MRPl.

Schmitt, L. Tampe, R. (2002) Structure and mechanism of ABC transporters. Curr. Opin. Struct. Biol. 12, 754-760. 

Schmitz G, Liebisch G, Langmann T. Lipidomic strategies to smdy structural and functional defects of ABC-transporters in cellular lipid trafficking. FEBS Lett. 2006 580 5597-5610. 

Linton, K.J. and Higgins, C.F. (2007) Structure and function of ABC transporters fhe ATP switch provides flexible control. Pflugers Archives, 453 (5), 555-567. 

Mendoza, J.L. and Thomas, P.J., Building an understanding of cystic fibrosis on the foundation of ABC transporter structures, J Bioenerg Biomembr 39 (2007) 499-505. 

Most ABC-transporters, especially those located in the plasma membrane, are phosphorylated and glycosylated transmembrane proteins of different molecular weights (e.g., P-gp 170 kDa MRP2 190 kDa BCRP 72 kDa). Topologically, most ABC-transporter show a similar structure they are organized in two transmembrane domains (TMD), each consisting of six... 

ABC Transporters. Figure 1 Structure of ABCB 1, ABCC1, and ABCG2 (NBF nucleotide binding fold TMD transmembrane domaine. Modified according to www.iwaki-kk.co.jp/bio/specialedition/se02.htm). 

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