Structure, Stereochemistry, Reactivity, Design

Design of macroheterocycles as selective complexing agents 87MI37 90UK1867. 

Molecular mechanics calculations of metal ion recognition by macroheterocycles 90ACR253. 

Ring size of macroheterocycles and their activity as complexing agents for metal ions 86PAC1445. 

Prediction of stereoselectivity based on MM calculations and syntheses of large ring natural products 89YGK135. 

Synthesis of macroheterocycles, monographs 87MI19, 87M137. Synthesis of macroheterocycles, some problems of 87YGK571. Template effect in macroheterocycle formation 86PAC1485. 

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Reactive intermediate chemistry assists chemists in the design of new reactions for the efficient synthesis of pharmaceuticals, fine chemicals and agricultural products. Reactive intermediates are usually short lived, very reactive and are rarely isolated under normal reaction conditions. However, their structures are established by indirect means either by chemical trapping, spectroscopically or sometimes by isolating them at very low temperature. The shapes of these intermediates become important while considering the stereochemistry of reactions in which they play a role. 

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