Structure-selectivity relationships systems biology

In this section several recently published studies on the interaction of nonionic surfactants with a variety of biological systems, including enzymes, bacteria, erythrocytes, leukocytes, membrane proteins, low density lipoproteins and membranes controlling absorption from the gastrointestinal tract, nasal and rectal cavities, will be assessed. This is a selective account, work having been reviewed that throws light on structure-activity relationships and on mechanisms of surfactant action. 

Our target is to ultimately fabricate reactive micro- and nanopatterns for the area-selective immobilization of biologically relevant molecules via covalent coupling. In addition to full control of reactivity and pattern sizes, biocompatibility and minimized NSA are important for rendering these systems useful as generic platforms. In this context we review in this contribution our recent efforts in this area. We focus in particular on (1) the elucidation of structure-reactivity relationships, (2) the in situ compositional analysis of wet chemical reactions in monolayer-based systems down to nanometer length scales, and on (3) the application and refinement of various micro- and... 

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