Structure of Pharmacokinetic Models

This equation describes the typical time course of amount of drug in the body (A) as a function of initial dose, time (t), and the first-order elimination rate constant (k). As was described by Equation 2.14, this rate constant equals the ratio of the elimination clearance (CLe) relative to the distribution volume of the drug ( d)/ so fhaf Equation 10.1 can then be expressed in terms of concentration in plasma (C ). 

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Weighted least squares (where W is typically 1/the observed concentration)  

Identify and investigate sources of variability that influence drug pharmacokinetics 

Estimate the magnitude of intersubject variability Estimate the random residual variability 

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