Structure of Diol Dehydrase

Diol dehydrase comprises three subunits and adopts a (aPy)2 structure. The a and y subunits are tightly associated with each other as an (ay)2 

FIGURE 13. The structure of diol dehydrase-cyanocobalamin complex. The top figure shows the complete a(3y trimer the lower figures show each subunit separately and its spatial relationship to the coenzyme, substrate and essential potassium ion. Reprinted from Shibata et ah, 1999, with permission from Elsevier Science. 

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Shibata, N., Masuda, J., Tobimatsu, T., Toraya, T., Suto, K., Morimoto, Y., and Yasuoka, N., 1999, A new mode of B12 binding and the direct participation of a potassium ion in enzyme catalysis X-ray structure of diol dehydrase. Structure 7 99701008. 

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