Structure, Conformation, and Spectral Studies

Crystal structures of 67 nucleosides and nucleotides have been examined in connection with calculations of orthogonal coordinates of the bases the evidence suggests that the mean geometry of each 

The mass spectra of TMS derivatives of nucleosides selectively labelled with deuterium and oxygen-18 have been recorded.The position of chlorine atoms in the carbohydrate ring of chloro-deoxy-nucleosides can be established from their mass spectrum. 

The desolvation of nucleoside hydrates in the crystal proceeds along a direction corresponding to one of the crystallographic axes. Ultrasonic methods have been used to study hydration of pyrimidine nucleosides and of D-ribose itself in aqueous-ethanolic solution. Variations in ultrasonic wave velocity with alcohol concentration could be related to the extent of interaction of the sugar hydroxy groups with water. 

Eberhard, and F.W. Lichtenthaler, Nucleic Acids Symp. Ser., 

Hasselmann, and H.-D. Winkeler, Justus Liebigs Ann. Chem. 

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