Structural Investigation of Crystal Surfaces and Structure Dehydration

1 Structural Investigation of Crystal Surfaces and Structure Dehydration 

An examination of the water position on the dominant (002) face (Fig. 6.15a) reveals that the water molecules are well protected by the molecule of erythromycin and are not exposed on the crystal surface of the particle. The crystal arrangement on this surface is very closely packed, binding the water molecule very tightly within the packing network. Due to this structural network, water molecules cannot be easily released from the structure through the surface. The (Oil) crystal face (Fig. 6.15b) reveals that the water molecules are very well exposed on this crystal surface. 

FIGURE 6.14 Predicted vacuum crystal morphology for erythromycin reveals that particle is dominated by the main (002) surface and the end (Oil) surface. 

FIGURE 6.15 (a) Molecular structure of the dominant (002) surface of erythromycin, 

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