Stroke neuroimaging studies

Since functional outcome and risk of recurrent stroke are, in part, predictable based on the pathophysiologic subtype of stroke, the ability to accurately classify patients based on emergency clinical and imaging data would provide valuable predictive information. Unfortunately, misclassifications of stroke subtypes based on clinical data and a noncontrast CT scan are common. The final subtyping of stroke is made with all available clinical data, but is heavily influenced by neuroimaging studies that identify the location, size, and vascular distribution of the infarct, or that establish that the arteries supplying the region of stroke are stenotic or occluded. 

Tohgi H, Takahashi S, Chiba K, Hirata Y. Cerebellar infarction. Clinical and neuroimaging analysis in 293 patients. The Tohoku Cerebellar Infarction Study Group. Stroke 1993 24 1697-1701. 

Bruhn H, Frahm J, Gyngell ML et at (1989). Cerebral metabolism in man after acute stroke new observations using localized proton NMR spectroscopy. Magnetic Resonance Medicine 9 126-131 Calautti C, Naccarato M, Jones PS et at (2007). The relationship between motor deficit and hemisphere activation balance after stroke a 3T fMRI study. Neuroimage 34 322-331... 

Multiple recently published studies of intravenous thrombolysis have demonstrated that neuroimaging of the ischemic penumbra can successfully guide therapy outside the 3-h window. In one study a novel fibrinolytic agent was evaluated up to 9 h from stroke onset [128] in the remaining studies, tPA was given between three to 6 h [53, 118,119, 124, 129]. 

Rossini PM, Altamura C, Ferreri F, Melgari JM, Tecchio M, Pasgualetti P, Vernieri F (2007) Neuroimaging experimental studies on brain plasticity in recovery from stroke. Eura Midicophys 43 241-254... 

---