Stress-70 protein family model

Fig. 2 A three-step model of p53 activation by stress signals. Activation of p53 requires covalent and noncovalent modifications in distinct domains of the protein. The first step involves phosphorylation in the N terminus, dissociation of complexes with mdm-2, and binding of histone-acetyl-transferases of the CBP/p300 family. The second step consists of coordinated modifications of the C terminus, including acetylation, changes in phosphorylation, and binding of specific proteins such as 14-3-3cr. The third step concerns the central portion of the protein and involves reduction of cysteines that play an important role in the conformation of the DNA-binding domain. For explanations and references, see text.

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