Streptomyces tubercidicus

Shirato reported the concentration process for the antibiotic tubercidan produced from fermented rice grain using the microorganism, Streptomyces tubercidicus. Macroporous strong acid cation resin was used to concentrate the antibiotic from 700 pg/ml in the fermentation broth to 13 mg/ml when eluted with 0.25 N HCl. The yield of the antibiotic was about 83%. 

Ibbercidin Streptomyces tubercidicus 4-Amino-7-pyrrolo- pyrimidine Ribose Adenosine... 

Tubereidin 6-amino-9-p-D-ribofuranosyl-7-deaza-purine, M, 266.25, m.p. 247-248 °C (d.), [a] j -67° (c = 1, 50% acetic acid), a purine antibiotic (see Nucleoside antibiotics) from Streptomyces tubercidicus, and one of the group of 7-deaza-adenine-nucleoside analogs. The N7 of adenine is replaced by a methylene group. T. is biosynthesized from adenosine (Fig.) the C-atoms of the pyrrole ring are derived from a ribose moiety, which is introduced from 5-phosphoribosyl 1-pyrophosphate. As an antimetabolite of adenosine, T. interferes with purine metabolism. T. can also be eonverted into nicotinamide-dea-za-adenine dinucleotide, which inhibits glycolysis. T. is particularly active against Mycobacterium tuberculosis and Candida albicans. 

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