Streptomyces thioluteus

It has been claimed that dimethyl phenazine-1,6-dicarboxylate (128) is a precursor for 1-carboxyphenazine in Pseudomonas aureofaciens cf. ref. 8. This claim has been disputed careful checking showed that neither (128) nor the corresponding acid (129) was incorporated into phenazines produced by this organism. This has been supported by the results of other workers, who have found that (128) is metabolically inert in P. aureofaciens. Moreover, neither (129) nor (128) was incorporated into phenazines in P. phenazinium. On the other hand, efficient incorporations have been recorded of (129), but not of (128), into iodinin (127) and related phenazines in three actinomycetes, i.e. Streptomyces thioluteus, Microbispora amethystogenes, and M parva ... 

C22H13NO6, Mr 397.43, yellow prisms, mp. 158 °C, [oJd +54° (CHCI3). Antibiotic isolated from various streptomycetes (e.g., Streptomyces thioluteus). A. exhibits antitumor activity, and has antifungal, anti-HIV, insecticidal, and herbicidal actions. 

Hirata Y, Nakata H, Okuhara K, Naito T, Yamada K (1961) Structure of aureothin, a nitro compound obtained from Streptomyces thioluteus. Tetrahedron 14 252-274... 

Pyran-pyranoid Compounds.—Aureotine Aureothin). Two research groups have independently examined separate features of the biosynthesis of Aureotine ( = Aureothin) (155), an antibiotic produced by Streptomyces thioluteus. 

Kawai, S., T. Oshima, and F. Egami Incorporation of oxygen atoms from molecular oxygen into the nitro group of -nitrobenzoate by Streptomyces thioluteus, Biochim. et Biophys. Acta 104, 316 (1965). 

Isol. from Acrospermum viticola, Brevibacterium iodinum, Calocybe gambosa, Microbispora aerata, Streptomyces thioluteus, Pycnoporus sp. and Waksmania sp. Active against gram-positive bacteria, mycobacteria, Candida albicans and shows antitumour activity. Phytotoxin. Used as a ImM soln. in EtOH as redox indicator for... 

---