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Streptomyces thermotolerans

JK Epp, SG Burgett, BE Schoner. Cloning and nucleotide sequence of a carbomycin resistance gene from Streptomyces thermotolerans. Gene 53 73-83, 1987. [Pg.109]

A Arisawa, N Kawamura, H Tsunekawa, K Okamura, H Tone, R Okamoto. Cloning and nucleotide sequences of two genes involved in the 4"-0-acylation of macrolide antibiotics from Streptomyces thermotolerans. Biosci Biotechnol Biochem 57 2020-2025, 1993. [Pg.109]

A Arisawa, N Kawamura, T Takeda, T Fujii, T Narita, I Kojima, K Okamura, H Tsunekawa, T Yoshioka, R Okamoto. Cloning of carbomycin biosynthesis genes from Streptomyces thermotolerans and its use for strain improvement. Abstracts Book of 10th International Symposium on Biology of Actinomycetes, Beijing, China, 1997, 12S5. [Pg.109]

The improved in vitro spectrum, in vivo efficacy, and pharmacokinetics of certain esters of leucomycin-related macrolides logically led to the synthesis of analogous esters of tylosin. 3- and 4"-0-acyl derivatives were initially prepared by bioconversions with Streptomyces thermotolerans, a producer of carbomycin [76], From this small group, 3-0-acetyl-4"-0-isovalerylty-losin (AlV-tylosin) (14) Figure 5.6) was chosen for further study because of its activity against some tylosin-resistant organisms and its improved oral therapeutic and pharmacokinetic effects [61, 77], AlV-tylosin has now been commercially developed as a new veterinary antibiotic. [Pg.273]

Carbomycin Antibacterial CYP107C1 (orf ) Streptomyces thermotolerans C12-C13 epoxidation of carbomycin B to make carbomycin C [789, 790]... [Pg.280]

Arisawa A, Tsunekawa H, Okamura K, Okamoto R (1995) Nucleotide-sequence analysis of the car-bomycin biosynthetic genes including the 3-o-acyl-transferase gene from Streptomyces thermotolerans. Biosci Biotechnol Biochem 59 582-588... [Pg.406]

Anthramycin is a benzodiazepine alkaloid with potent antitumor and antibiotic activity produced by the thermophilic actinomycete Streptomyces refuineus sbsp. thermotolerans. Using a genome-scanning approach, the biosynthesis was found to involve condensation of 4 methyl-3-hydroxy anthranilic acid 136 and a... [Pg.446]

Anthramycin.—The aromatic ring of tyrosine suffers minor modification on incorporation into securinine (see above) whilst utilization in betalain biosynthesis results in ring cleavage between C-3 and C-4 after hydroxylation to dopa (see below). Similar degradation of tyrosine occurs in the biosynthesis of anthramycin (166), an antibiotic produced by Streptomyces refuineus. var thermotolerans. ... [Pg.40]

See other pages where Streptomyces thermotolerans is mentioned: [Pg.91]    [Pg.50]    [Pg.91]    [Pg.50]    [Pg.108]    [Pg.205]    [Pg.36]   
See also in sourсe #XX -- [ Pg.91 , Pg.93 , Pg.97 , Pg.101 ]

See also in sourсe #XX -- [ Pg.50 ]

See also in sourсe #XX -- [ Pg.156 , Pg.170 ]



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