Streptomyces pulveraceus

Fostriecin (20, CI-920) is a novel metabolite of Streptomyces pulveraceus that was first isolated in 1983 by a research group at Warner Lambert-Parke Davis.22 It displays antitumor activity against a broad range of cancerous cell lines in vitro. This activity is suggested to be intimately related to the potent and highly selective inhibitory activity against serine/threonine phosphatase PP2A.23 In fact, fostriecin is the most selective protein phosphatase inhibitor reported to date, and it... 

C H270,P, Mr 430.39, [a]o +33° (buffer pH 7), a polyene lactone produced by Streptomyces pulveraceus with activity against yeasts and tumor cells (especially leukemia). It is a specific inhibitor of topoisomerase II (EC 5.99.1.2), but does not bind to DNA and does not effect strand cleavage. 

Fostriecin Antitumor FosK Streptomyces pulveraceus C18 fostriecin hydroxylation [153,798]... 

Kong R, Liu X, Su C, Ma C, Qiu R, Tang L (2013) Elucidation of the biosynthetic gene cluster and the post-PKS modification mechanism for fostriecin in Streptomyces pulveraceus. Chem Biol 20 45-54... 

The total synthesis of PD 113.271, an antitumor fostriecin analogue (55) isolated from Streptomyces pulveraceus was achieved by the chiral pool approach starting with D-galactose and L-tartaric acid. Its synthesis led to the unambiguous assignment... 

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