Reductomycin from Streptomyces orientalis

As with reductomycin (59), reductiline (60) has been isolated from the fermentation broth of a variant of Streptomyces orientalis [122]. Its structure is related to reductomycin (59), the difference being that the acetoxydihydrofuran unit has been substituted by the N-(3-methylthiopropyl)pyrrole. Biogenetically, reductiline (60) could be considered to originate from reductiomycin (59) and methionine. The synthesis of reductiline (60) has been carried out from formylated (1-cyanopropanal dimethylacetal. After condensation of this aldehyde with... 

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