Streptomyces griseus antibacterial activity

In the purposeful search that followed the demonstration of the clinical efficacy of penicillin, streptomycin was obtained from Streptomyces griseus in 1944, cultured from a heavily manured field, and also from a chicken s throat. Aminoglycosides resemble each other in their mode of action, and their pharmacokinetic, therapeutic and toxic properties. The main differences in usage reflect variation in their range of antibacterial activity crossresistance is variable. 

C27H49N7O17 743.721 Aminoglycoside antibiotic. Occurs together with Streptomycin in certain cultures of Streptomyces griseus. Shows antibacterial activity similar to Streptomycin. 

First, on their antibacterial activity of phaseolin [(-)-phaseollin, 39] at concentration 10 pg/disk, Corynbacterium fascians was the highest area of inhibition (mm )(ai) 59, followed hy Mycobacterium phlei ai 38, Micrococcus roseus ai 16, Streptomyces griseus ai 10, Bacillus subtilis ai 8, Bacillus megaterium ai 8 and Micrococcus luteus ai 5, respectively. 

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