Streptomyces griseosporeus

S. Murao, A. Goto, Y. Matsui, and K. Ohyama,New proteinous inhibitor (Haim) of animal a-amylase from Streptomyces griseosporeus YM-25, Agric. Biol. Chem., 44 (1980) 1679-1681. 

Mirza, S, Molleyres, L P, Vasella, A, Synthesis of a glyoxylase I inhibitor from Streptomyces griseosporeus Niida et Ogasawara, Helv. Chim. Acta, 68, 988-996, 1985. 

FK 409 (FR 900409 4-ethyl-2-(hydroxyimino)-5-nitro-3-hexenamide) is produced by Streptomyces griseosporeus. It is a nitric oxide releaser (in solution at pH 7.4), acting as a NITRERGIC STIMULANT. It iS a PLATELET AGGREGATION INHIBITOR... 

C8H13N3O4, Mr 215.21, mp. 140°C, optically inactive, isolated from cultures of Streptomyces griseosporeus after acidification (pH 3) prior to extraction. It is also obtained semisynthetically from FR-900411 (4-ethyl-2,4-hexadienoic acid amide CjH,3NO, Mr 139.20, mp. 57-58°C) produced by the strain through reduction... 

Ethyl-2 [ (Z)-hydroxyiminol] -5-nitro-3( )-hexene-amide (FK409) is a semi-artifidal fermentation product of Streptomyces griseosporeus No. 16917 that spontaneously generates NO and possesses potent vaso-relaxant and anti-platelet activities (Fukuyama et al. 1995). It is relative unstable, with a half-life of approximately 45 min at 37 C in phosphate buffer. FK409 has been reported to attenuate experimental liver (Ohmori et al. 1998), cardiac (IsoNO et al. 1993), pulmonary (Takeyoshi et al. 

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