Streptomyces, glutamine synthetase inhibitor

C4H7NO3, Mr 117.10, mp. 185-190°C (decomp.), [o]d +56.4° (HjO). A non-proteinogenic amino acid with antibacterial and herbicidal activities produced by a Streptomyces species. O. is a non-competitive inhibitor of glutamine synthetase. Although only the natural (2/ )-c/s-form is active against bacteria, the other isomers also function as inhibitors of glutamine synthetase. ... 

Produced by Streptomyces viridoc/iro mogenes inhibitor of glutamine synthetase used as nonspecific postemergeni herbicide. 

Glufosinate (GA) is a post-emergence and nonselective herbicide [91, 92], The L-enantiomer of this herbicide, which is also called phos-phinothricin, is a natural microbial phytotoxin, produced by Strepto-myces viridochromogenes and Streptomyces hygroscopicus, and acts as an inhibitor of glutamine synthetase, while the D-enantiomer shows no activity on this enzyme. The herbicidal action involves a rapid accumulation of ammonia, a deficiency in several amino acids, an inhibition of photosynthesis and, finally, the death of the plant cell [91, 93]. 

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