Streptokinase adverse reaction

Streptokinase is not used for restoring IV catheter patency. Serious adverse reactions induding hypotension, hypersensitivity apnea, and bleeding, have occurred when the drug is used for this purpose. 

Allergic reactions Approximately 53% of all allergic reactions or suspected allergic reactions occurred in patients who concomitantly received thrombolytic therapy (eg, streptokinase) for acute Ml or contrast media for coronary angiography (see Adverse Reactions). 

Q9 A patient who has recently received a head injury, or had surgery, or who has haemorrhaged recently may bleed excessively in this situation, thrombolytics are contraindicated. These drugs are also unsuitable for patients who have previously experienced an adverse reaction to one of the drugs, such as an allergic reaction to streptokinase. 

Montserrat I, Altimiras J, Dominguez M, Lamich R, Olle A, Fontcuberta J. Adverse reaction to streptokinase with multiple systemic manifestations. Pharm World Sci 1995 17(5) 168-71. 

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