Streptococcus analogs

Several tetrahydroquinazoline analogs of folic acid were synthesized by Baker and co-workers as potential anticancer agents, and the substance (61), at 50 m/ g/ml, gave a 50% inhibition of growth of Streptococcus faecalis on a Flynn folic acid medium containing 3 m/i,g of folic acid. 

A number of deaza analogs of pteroic acid (182, Ri = R2 = OH) have been prepared and examined by Rydon el al. as antagonists of folic acid in Streptococcus faecalis and Lactobacillus casei. Two of the pyrido[3,2-d]pyrimidines (183, R = OH or OEt, R2 = NH2) showed... 

CM101 Analog of group B streptococcus toxin, binds to tumor endothelium, induces inflammation... 

The transpeptidase activity of PBPs is well characterized, mainly due to its important role in bacterial resistance to P-lactam antibiotics [1-3,15,23-27], The transpeptidase activity can be characterized by its ability to bind to different P-lactams and to hydrolyze analogs of bacterial cell wall stem peptides [1,2,15,28-35], A crystal structure has been described for the transpeptidase domain of the Streptococcus pneumoniae PBP2x protein, a member of class B PBPs [36],... 

One of the second type of inhibitor analogs which cause a time-dependent inactivation of alanine racemase is (l-aminoethyl)phosphonic acid, the phosphonate analog of alanine (Ala-P). Ala-P effectively and specifically inactivates alanine racemases from Grampositive bacteria (Bacillus, Staphylococcus, Streptococcus), and serves as a reversible inhibitor of Gram-negative bacterial (Escherichia, Salmonella) alanine racemase.47 53 The mechanism of inhibition was studied with B. stearothermophihis alanine racemase.47 The d- or L-Ala-P leads to an E-I complex with a Ki value of 1 mM, then is slowly isomerized (A nac<=6-9 min-1) to a stoichiometric enzyme complex (E-I ). The Ed dissociates extremely slowly with the... 

Diazaquinomycin A (257) is produced by a Streptomyces species and exhibits antibacterial activity. It is also an antimetabolite of folate metabolism in Streptococcus faecium. Its structural analogs were synthesized (83TL3643). 

Thaniyavarn, S., Taylor, K.G., Singh, S., and Doyle, R.J. (1982) Pyridine analogs inhibit the glucosyltransferase of Streptococcus mutans. Infect. Immun. 37, 1101-1111. 

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