Stratum corneum parakeratotic cells

The process of nucleic acid breakdown presumably starts a little before entry of the cell into the granular layer. Histochemically, however, most lysosomal enzymes are strongest at the level of the granular layer (B28). The amount of DNA in psoriatic epidermis is equivalent per unit weight to normal epidermis, but about one-third of the nuclear DNA is still present in the parakeratotic horny layer of psoriasis while practically none is found in normal stratum corneum. RNA is much increased in psoriatic epidermis (M12, R5), and it also can be found in increased amounts in the psoriatic scale (Table 6). 

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