Strategy bias parameter

Of particular interest is the utility of population modeling when sampling is limited, as is often the case in pediatric studies. For example, etoposide toxicity and efficacy have been related to exposure. It was not reasonable to execute an intense sampling PK study in the pediatric population, therefore a limited sampling strategy was proposed and done. In each subject only two samples were collected—one at about 3 hours postdose and another 5.5 hours postdose. The approach was shown to be able to estimate PK parameters that had little bias (18). 

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