Stirring in the Small Intestine

Muscular contractions in the wall of the small intestine have to achieve two objectives first, stirring of the contents to 

Exposure of the intestinal cells to high concentrations of polyethylene glycol 2000 causes villus shortening, goblet cell capping, and destruction of the villus tip (35). The effects of smaller molecular weight materials were more extreme and 

Dispersion of material following timed release in the colon using Pulsincap devices. Mean s.d. 

For most formulations, colonic absorption represents the only real opportunity to increase the interval between dosing. Transit through the lower part of the gut is quoted at around 24 hr, but in reality only the ascending colonic environment has sufficient fluid to facilitate dissolution. The supplementa- 

In the cecum, the fermentation of any soluble fiber present produces short chain fatty acids (SCFA) and gas (largely 

---