Stimulus generalization studies

TABLE 1. Results of stimulus generalization studies using racemic DOM as... 

Table 23.1. Results of Stimulus Generalization Studies with Examples from the Various Categories of Classical Hallucinogens Using Animais Trained to...

Figure 3. Results of stimulus antagonism and stimulus generalization studies with DOBZ (7) in DOM-trained rats. (DOBZ was administered 10 min prior to DOM in the antagonism studies, and in the absence of DOM in the agonism studies. Doses of DOBZ greater than 0.4 mg/kg in the antagonism studies resulted in disruption of behavior. In the agonism studies, 1.5 and 1.8 mg/kg of DOBZ produced disruption of behavior. DOM - the effect of 1 mg/kg of DOM, and S - the effect of saline.)...

Figure 5. Results of stimulus antagonism and stimulus generalization studies with DOTB (14) in DOM-trained rats. Open triangle represents the effect of DOM in the absence of DOTB solid squares represent the effect of DOTB administered 1 min prior to 1 mg/kg of DOM (upper curve) or, in the control studies, 1 min prior to 1 mL/kg of saline (lower curve). D disruption of responding. [A preliminary account of this work has been reported (14).]...

Bufotenine has been found to be behaviorally inactive, or only weakly active, in most animal studies, although at 15 mg/kg, it did produce the head-twitch resonse in mice (43). It was also behaviorally active in experiments in which the blood-brain barrier was bypassed (78). Acylation of the polar hydroxy group of bufotenine increases its lipid solubility (65,74) and apparently enhances its ability to cross the blood-brain barrier (64). For example, O-acetylbufotenine (5-acetoxy-N,N-dimethyltryptamine 54) disrupted conditioned avoidance behavior in rodents (65) and produced tremorigenic activity similar to that elicited by DMT (37) or 5-OMeDMT (59) when administered to mice (64). In this latter study, a comparison of brain levels of bufotenine after administration of O-acetylbufotenine with those of DMT and 5-OMeDMT revealed bufotenine to be the most active of the three agents, based on brain concentration. The pivaloyl ester of bufotenine also appears to possess behavioral activity, since stimulus generalization was observed when this agent was administered to animals trained to discriminate 5-OMeDMT from saline (74). 

Atmospheric chemistry demands have given a nuuked stimulus to studies of reactions of 0 atoms and OH- radicals with atmospheric substrates at about room temperature and below. Reactions of O atoms with alkenes and aromatics are important in photochemical smog formation and control. Rate constants, and in many cases Arrhenius parameters, are available for a variety of -O atom reactions with alkenes, alkynes, aromatics, unsaturated aldehydes, alkanes, - and carbonyl compounds. In general, the rate constants refer to the ovoall process ... 

It was generally assumed that it cannot and this became known as Dale s Law. During his studies on antidromic vasodilation he wrote (1935) When we are dealing with two different endings of the same sensory neuron, the one peripheral and concerned with vasodilation and the other at a central synapse, can we suppose that the discovery and identification of a chemical transmitter at axon reflex dilation would furnish a hint as to the nature of the transmission process at a central synapse. The possibility has at least some value as a stimulus to further experiments . 

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