Stimulates pepsinogen secretion

Qll Both alcohol and the caffeine content of coffee act directly on the gastric mucosa to stimulate acid and pepsinogen secretion, so reduction in their use should help the patient. Smoking can also worsen dyspepsia (indigestion) and heartburn, possibly via actions of nicotine on the stomach wall. 

Entry of protein in to stomach stimulates gastric mucosa to secreate the hormone gastrin. Which stimulates the secretion of hydrochloric acid by the parietal cells of gastric glands and pepsinogen by the chief cells. 

Gastrins stimulate the secretion of gastric acid, pepsinogen, intrinsic factor, and secretin stimulate intestinal mucosal growth increase gastric and intestinal motility... 

Leonard Johnson, working with me as a graduate student after my return to Michigan, demonstrated that back-diffusion of acid liberates histamine within the mucosa. Liberated histamine stimulates acid secretion and increases mucosal capillary permeability, with the result that the mucosa sheds plasma proteins of all molecular weights. In addition, Johnson showed later that back-diffusion of acid stimulates secretion of pepsinogen through a cholinergic reflex. 

As with other 6-adrenergic systems, stimulation of pepsinogen secretion by isoproterenol is associated with activation of adenylate cyclase and an increase in cellular cAMP. 

Gastrin is a hormone produced by gastric endocrine tissue — specifically, the G cells in the pyloric gland area. It is released into the blood and carried back to the stomach. The major function of gastrin is to enhance acid secretion by directly stimulating parietal cells (HC1) and chief cells (pepsinogen). Gastrin also stimulates the local release of histamine from enterochromaf-fin-like cells in the wall of the stomach. Histamine stimulates parietal cells to release HC1. 

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