Stilbenoids bioactivities

The work on stilbenoids was reviewed by Gorham in 1995 [4]. Herein, we review the recent progress in the studies of stilbenoids with respect to their structure, distribution, extraction and isolation, technologies used in structure identification, synthesis and biosynthesis, and the last but not the least, bioactivities. The coverage of the new structures is from 1994 (especially those that have not been covered by Gorham [4]) to June 2006 (the references in 2006 may not be collected thoroughly as some of them might have not been included in the databases yet). 

Stilbenes are the most heavily investigated small molecules for bioactivities of all the stilbenoids, especially resveratrol (1) and its analogs. In this review, stilbenes are classified into five groups ... 

Bibenzyls bioactivities biosynthesis bisbibenzyls occurrence oUgostilbenes phenanthrenes phytochemistry stilbenes stilbenoids... 

Resveratrol (Fig. 4), a bioactive stilbenoid found in nuts and wine from red grapes, has antioxidant, anti-thrombotic, and anti-inflammatory properties (Labinskyy et al, 2006). It also inhibits carcinogenesis in animal models of breast cancer (Whitsett et al, 2006). Muscadine grape skin extract causes phosphatidylinositol 3-kinase Akt-dependent apoptosis in prostate cancer cell Unes, but not prostate epithelial cells (Hudson et al, 2007). This is different from res-veratrol s effects in the prostate cancer cells which are concentrated on inhibition of the... 

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